Clinical reference
CFTR Modulator · Cystic fibrosis transmembrane conductance regulator corrector and potentiator · Pulmonology, Pediatrics, Cystic Fibrosis
Lumacaftor and ivacaftor (Orkambi) is a fixed combination: lumacaftor is a CFTR corrector and ivacaftor is a CFTR potentiator, indicated for cystic fibrosis in individuals with homozygous F508del CFTR mutation. Formulations: Oral granules (lumacaftor:ivacaftor) 75 mg:94 mg (14 packets), 100 mg:125 mg (56 packets), 150 mg:188 mg (56 packets); Tablets 100 m…