Clinical reference
Antiretroviral · Nucleoside reverse transcriptase inhibitor (NRTI) · Neonatology, Infectious Diseases
NRTI for HIV-1 infection in combination with other antiretrovirals in children ≥2 weeks. Manufacturer dose: 100 mg/m² PO twice daily; guideline suggests 50 mg/m² twice daily may be more appropriate for neonates. Give on empty stomach (30 min before or 2 h after feeding). Black box: pancreatitis, lactic acidosis, hepatomegaly with steatosis; contraindicate…