Sulfamethoxazole and Trimethoprim (Trimethoprim-sulfamethoxazole (TMP-SMX; co-trimoxazole)) — dosing & safety
Sulfamethoxazole and Trimethoprim (Trimethoprim-sulfamethoxazole (TMP-SMX; co-trimoxazole))
Antibiotic, sulfonamide derivative · Combination folate synthesis inhibitor · Infectious Disease, Pediatrics, HIV Medicine
Sulfamethoxazole and trimethoprim (TMP-SMX) is an oral and intravenous combination antibiotic consisting of the sulfonamide sulfamethoxazole and the diaminopyrimidine trimethoprim, typically in a 5:1 SMX:TMP ratio. It is used for a wide range of bacterial infections and for treatment and prophylaxis of Pneumocystis jirovecii (carinii) pneumonia (PCP). Ora…
Common clinical indications
Treatment of minor to moderate bacterial infections due to susceptible organisms (e.g., urinary tract infections, otitis media, certain respiratory infections).
Treatment of severe infections due to susceptible organisms (per local guidelines).
Treatment and prophylaxis of Pneumocystis jirovecii (carinii) pneumonia (PCP).
Urinary tract infection (UTI) prophylaxis in selected patients.
What is Sulfamethoxazole and Trimethoprim used for?
Sulfamethoxazole and Trimethoprim (Trimethoprim-sulfamethoxazole (TMP-SMX; co-trimoxazole)) is listed in YMed Atlas under Antibiotic, sulfonamide derivative. Indications, dosing, and safety information on this page summarize curated references—always confirm with current labeling, formularies, and local protocols.
How do I adjust dosing for renal impairment or special populations?
Review the dosing sections and references for this monograph. Many agents require renal or hepatic adjustment; pediatric, pregnancy, and lactation considerations are clinician-specific. This interface is educational and does not replace individualized prescribing decisions.
Is this medical advice?
No. YMed Atlas drug pages support learning and quick reference. They are not a substitute for clinical judgment, pharmacist review, or formal interaction checking with a complete medication list.
