Clinical reference
Antiparasitic agent · Folate antagonist; antiprotozoal · Infectious Disease, Pediatrics, Neurology
Pyrimethamine is a folate antagonist antiprotozoal agent used primarily in combination regimens for the treatment of toxoplasmosis, including congenital toxoplasmosis and toxoplasmosis in immunocompetent and HIV-exposed/positive patients. It is typically administered with a sulfonamide (e.g., sulfadiazine or trisulfapyrimidines) and folinic acid (leucovor…