Clinical reference
Antidote, heparin · Heparin antagonist; cationic protein · Critical Care, Cardiology, Hematology, Anesthesiology
Protamine sulfate is a strongly basic, positively charged polypeptide used as a specific antidote for heparin and as a partial reversal agent for low-molecular-weight heparins (e.g., enoxaparin). It forms stable complexes with heparin, neutralizing its anticoagulant activity. Available as a preservative-free injection: 10 mg/mL (5, 25 mL).