Clinical reference
Anticonvulsant / Local anesthetic · Sodium channel blocker (CNS use for seizures) · Neonatology, Neurology
Lidocaine IV used for severe recurrent or prolonged neonatal seizures refractory to first-line therapies. Term, normothermic: load 2 mg/kg IV over 10 min, then infusion 6 mg/kg/hr x 6 h, 4 mg/kg/hr x 12 h, 2 mg/kg/hr x 12 h. Preterm and hypothermia: risk of accumulation; precise dosing uncertain. Use preservative-free, no epinephrine. Do not use with phen…