Clinical reference
Uric acid lowering agent · Xanthine oxidase inhibitor · Rheumatology, Oncology, Nephrology, Pediatrics
Allopurinol is a xanthine oxidase inhibitor used to lower uric acid. Used in tumor lysis syndrome (see Chapter 22 for additional information). Consider genomic testing: avoid use in individuals with HLA-B*58:01 allele due to significant risk of severe cutaneous adverse reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis). Formulations: T…